Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section

ConditionPostoperative Ileus

Trial statusRecruiting

Trial phasePhase 1, Phase 2

Trial typeInterventional

Biological sexFemale

Age18-40

SponsorAssiut University

About this trial

Postoperative ileus is a perplexing problem for clinical surgeons. It occurs not only after abdominal surgery but also after any surgery that requires general anesthesia. Postoperative ileus is defined as the dysfunction of gastrointestinal motility after surgery, characterized by a decrease in, or stagnation of, intestinal peristalsis.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

•All participants will sign an informed consent prior to inclusion in the study.

All patients 18-40 years of full-term singleton pregnancy (37-41 weeks).,

American Society of Anaesthesiologists (ASA) classification class I and II scheduled.

for elective or semi-elective surgery (category 3 and 4 Caesarean sections).

Disqualifiers

will be patients' height < 150 or > 180 cm.

Body mass index (BMI) >35 kg m-2.

Contraindication or refusal to undergo regional anesthesia.

any cardiovascular disease including arrhythmias and severe stenotic valvular heart disease.any renal or hepatic diseased patients.

Trial design

Design model

Parallel

Treatments tested in this trial

0.9%sodium chloride
Drug
Patients received 5 ml of IV normal saline as a placebo just before spinal anesthesia
Dexamethasone
Drug
Patients received IV dexamethasone 8 mg in 5ml normal saline 0,9%, just before spinal anesthesia.

Treatment groups

90 Participants

are divided into 2 treatment groups

Group A: Group CPlacebo comparator 1 intervention

Group B: Group DActive comparator 1 intervention

Trial outcomes

Primary outcomes

the time to first passage of flatus and or stool

the time to first passage of flatus and or stool through the first 24 hours and the time of return of intestinal sounds,

Time frame

24 hours postoperative

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

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