Dexmedetomidine and Magnesium Sulfate in the Reduction Cognitive Dysfunction in Geriatrics

ConditionMental Disorder

Trial statusRecruiting

Trial phasePhase 1

Trial typeInterventional

Biological sexAll

Age60-80

SponsorFayoum University

About this trial

Magnesium sulfate is considered a neuroprotective drug and has been studied in various applications. Recently, it has drawn the attention of anesthesiologists, resulting in numerous publications about its role in anesthesiology.

Magnesium sulfate is suggested to exert its neuroprotective effect by preventing excitotoxicity. in the clinical setting, intraoperative magnesium sulfate attenuated POCD. Furthermore, postoperative emergence agitation was significantly reduced in pediatric patients who received intraoperative magnesium sulfate during adenotonsillectomy.

The aim of this study The aim of this work is to compare the protective effect of intraoperative dexmedetomidine with magnesium sulfate against developing POCD and to study their effect on serum level of CRP; the marker of neuronal degeneration.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

ASA physical status I, II and ⅠⅠⅠ

patients undergoing open abdominal surgery under general anesthesia

Disqualifiers

Elderly patients with preoperative MoCA Score below 26.

Operation time more than 4 hours to prevent excessive dosage of magnesium sulfate.

BMI > 35 kg m-2

Trial design

Design model

Parallel

Treatments tested in this trial

dexmedetomidine
Drug
20 mg/kg as a loading dose over 10 minutes before induction then a maintenance dose of 5 mg/kg/hour, which will also be discontinued at the skin closure.

Treatment groups

58 Participants

are divided into 2 treatment groups

Group A: The dexmedetomidineActive comparator 1 intervention

Group B: The magnesium sulfateActive comparator 1 intervention

Trial outcomes

Primary outcomes

the incidence of Post Operative Cognitive Dysfunction

Post Operative Cognitive Dysfunction

Time frame

24 hours postoperative

Secondary outcomes

CRP levels and their correlation with POCD

Time frame

24 hours of postoperative

Sponsors and contacts

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Fayoum University

Lead sponsor

Source ClinicalTrials.gov

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