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Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients

ConditionHaemodynamic Rebound
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-70
SponsorNew Valley University

About this trial

Inflammatory response and hemodynamic response in patients with intraabdominal sepsis and Effects of Dexmedetomidine versus ketamine on it .

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

• Adult patients admitted to ICU after ileus surgery (perforated viscus, infarcted bowel, strangulated hernia, anastomotic leakage, diverticulitis, and intestinal obstruction), and who will be expected to require postoperative sedation and ventilation.

Abdominal sepsis was determined as organ dysfunction with a substantial change in overall SOFA score (2) ≥ 2 points because of intra-abdominal sepsis.

Disqualifiers

• Known allergy to ketamine, dexmedetomidine,

Confirmed pregnancy,

Heart failure (class 3 or 4 of the New York Heart Association),

Renal failure (RIFLE classification),

Trial design

Design model

Parallel

Treatments tested in this trial

  • Dexmedetomidine

    Drug

    Patients will receive dexmedetomidine

  • Ketamine

    Drug

    patients Will receive ketamine

Treatment groups

2 Participants
are divided into 2 treatment groups
Group A: Patients will receive dexmedetomidineActive comparator 1 intervention
Group B: Patients will receive ketamineActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

blood pressure

Effect of the study drugs as sedative agents on blood pressure in mechanically ventilated septic patients after abdominal exploration for intestinal surgery.

Time frame
48 hours

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

New Valley University

Lead sponsor

Source ClinicalTrials.gov
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