Effects of Neostigmine-dose on Diaphragmatic Dynamics
ConditionDiaphragm Ultrasound
Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-75
SponsorAswan University Hospital
About this trial
The goal of this Randomized Clinical Trial is to compare the postoperative diaphragmatic excursion between patients receiving half-dose neostigmine (0.04 mg/kg) and those receiving full-dose neostigmine (0.08 mg/kg) for neuromuscular blockade reversal.
The main questions it aims to answer are:
* Does half-dose neostigmine result in similar postoperative diaphragmatic excursion compared to full-dose neostigmine? * Does half-dose neostigmine result in similar diaphragmatic thickening fraction compared to full-dose neostigmine? Researchers will compare patients receiving half-dose neostigmine to those receiving full-dose neostigmine to see if there are differences in postoperative diaphragmatic function, respiratory complications, and recovery.
Participants will:
* Undergo elective laparoscopic cholecystectomy. * Receive either half-dose or full-dose neostigmine for neuromuscular blockade reversal.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults scheduled for elective laparoscopic cholecystectomy.
Age: < or = 18 years.
Both genders.
American Society Of Anesthiologists (ASA) I/II patients.
Disqualifiers
Pre-existing diaphragmatic or respiratory disorders.
ASA III/IV
BMI >35
Chronic opioid use or abuse
Trial design
Design model
Parallel
Treatments tested in this trial
full dose of Neostigmine
Drug• Group A: received 10ml (a full dose of Neostigmine (0.08 mg/kg) plus Atropine (20 mic/kg+7ml normal saline) Measured using ultrasound Time frame: preoperatively and at zero, 10 minutes and 30 minutes postoperatively.
half dose of Neostigmine
Drug• Group B: received 10ml (a half dose of Neostigmine (0.04 mg/kg) plus Atropine (20 mic/kg+8ml normal saline). Measured using ultrasound Time frame: preoperatively and at zero, 10 minutes and 30 minutes postoperatively.
Treatment groups
50 Participants
are divided into 2 treatment groupsGroup A: full dose of NeostigmineActive comparator 1 intervention
Group B: half dose of NeostigmineActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Diaphragmatic Dynamics
To compare the postoperative diaphragmatic excursion between patients receiving half-dose neostigmine (0.04 mg/kg) and those receiving full-dose neostigmine (0.08 mg/kg) for neuromuscular blockade reversal.
Time frame
preoperatively and at zero, 10 minutes and 30 minutes postoperativelyLocations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: