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Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals

ConditionHealthy Individuals
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-40
SponsorUniversidade Federal de Pernambuco

About this trial

This study investigates the immediate effects of different parameters (frequency, intensity, and pulse number) of peripheral magnetic stimulation (rPMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEPs), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Crossover

Treatments tested in this trial

  • Peripheral magnetic stimulation (90% of RMT + 1 Hz)

    Device

    Low-frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

  • Peripheral magnetic stimulation (90% of RMT + 10 Hz)

    Device

    High-frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, totaling 2400 pulses.

  • Peripheral magnetic stimulation (90% of RMT + 25 Hz)

    Device

    High-frequency stimulation (25 Hz) at 90% of resting muscle threshold intensity, with 2400 pulses.

  • Peripheral magnetic stimulation (100% of RMT + 1 Hz)

    Device

    Low-frequency (1 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.

  • Peripheral magnetic stimulation (100% of RMT + 10 Hz)

    Device

    High-frequency (10 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.

  • Peripheral magnetic stimulation (100% of RMT + 25 Hz)

    Device

    High-frequency (25 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.

  • Peripheral magnetic stimulation (110% of RMT + 1Hz)

    Device

    Low-frequency (1 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.

  • Peripheral magnetic stimulation (110% of RMT + 10Hz)

    Device

    High-frequency (10 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.

  • Peripheral magnetic stimulation (110% of RMT + 25Hz)

    Device

    High-frequency (25 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.

Treatment groups

18 Participants
are divided into 9 treatment groups

9

Treatment groups

See each treatment group below.

Group A: Peripheral magnetic stimulation (90% + 1 Hz)Active comparator 1 intervention
Group B: Peripheral magnetic stimulation (100% + 25 Hz)Active comparator 1 intervention
Group C: Peripheral magnetic stimulation (90% + 25 Hz)Active comparator 1 intervention
Group D: Peripheral magnetic stimulation (100% + 1 Hz)Active comparator 1 intervention
Group E: Peripheral magnetic stimulation (100% + 10 Hz)Active comparator 1 intervention
Group F: Peripheral magnetic stimulation (110% + 1 Hz)Active comparator 1 intervention
Group G: Peripheral magnetic stimulation (110% + 10 Hz)Active comparator 1 intervention
Group H: Peripheral magnetic stimulation (110% + 25 Hz)Active comparator 1 intervention
Group I: Peripheral magnetic stimulation (90% + 10 Hz)Active comparator 1 intervention

Trial outcomes

Primary outcomes

1

Cortical excitabilty

Cortical excitability will be assessed through motor-evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS) over the primary motor cortex (M1), targeting the first dorsal interosseous (FDI) representation area. The hotspot will be determined as the site producing the largest MEP amplitude at the lowest intensity, with stimulation delivered at 100% of the resting motor threshold (RMT). Additionally, paired-pulse TMS protocols will evaluate intracortical inhibition (ICI) and facilitation (ICF) using conditioning stimuli at 80% RMT (3 ms interstimulus interval for ICI, 10 ms for ICF) and test stimuli at 120% RMT. MEP amplitudes will be recorded via surface electromyography (EMG) from the FDI muscle using bipolar electrode placement, with signals sampled at 20,000 Hz (bandpass 5-10,000 Hz) to capture corticospinal excitability changes across timepoints (baseline, post-intervention, and follow-ups).

Time frame
Baseline (T0), immediately post-stimulation (T1), 15 minutes (T2), and 30 minutes (T3) post-stimulation.

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Universidade Federal de Pernambuco

Lead sponsor

Source ClinicalTrials.gov
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