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Evaluate the Safety and Tolerability of Multiple Doses of JMT206 Injection in Obese Participants

ConditionValid MeSH Conditiongs
Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-65
SponsorShanghai JMT-Bio Inc.

About this trial

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Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18~65 (including threshold values), male or female participants;

BMI ≥ 30 kg/m²;

Weight change <5% within the 3 months prior to screening

Voluntarily sign the informed consent form before the trial..

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • JMT206 injection

    Drug

    JMT206 injection administered subcutaneously (SC) once a week

  • Semaglutide injection

    Combination product

    Semaglutide administered subcutaneously once a week, starts from lower dose and is gradually increased.

  • Placebo injection

    Drug

    Placebo administered subcutaneously (SC) once a week.

Treatment groups

90 Participants
are divided into 8 treatment groups

8

Treatment groups

See each treatment group below.

Group A: JMT206 injection group 2Experimental treatment 1 intervention
Group B: JMT206 injection group 3Experimental treatment 1 intervention
Group C: JMT206 injection + Semaglutide group 1Experimental treatment 2 interventions
Group D: JMT206 injection + Semaglutide group 2Experimental treatment 2 interventions
Group E: JMT206 injection + Semaglutide group 3Experimental treatment 2 interventions
Group F: PlaceboPlacebo comparator 1 intervention
Group G: Placebo+ SemaglutidePlacebo comparator 2 interventions
Group H: JMT206 injection group 1Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Incidence of Adverse Events (AE) assessed by CTCAE v6.0

Time frame
Baseline through week 19

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Shanghai JMT-Bio Inc.

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: