it is a randomized control trial and aims at investigating the effects of PRF on rate of tooth movement and root length to be tested on larger sample size of pakistani population
Patients who give written consent to participate in the research
Orthodontic patients with good oral hygiene
Patients with periodontal probing depths≤3 mm with no bone loss
Patients undergoing orthodontic treatment with fixed appliance and requiring upper first premolar extraction followed by canine retraction
patients who are smokers, health compromised (such as diabetics, with bone disorders, immunocompromised, known with blood dyscrasias) will be excluded from the trial. Patients with drug history of non-steroidal anti-inflammatory drugs, anti-inflammatory (in last 30 days), antibiotic therapy in last 3 months and those women who are pregnant will also be excluded.
Parallel
Platelet rich fibrin
Biological/VaccineOnly the test side that will be intervened with i-PRF will be obtained from the upper liquid layer and will be placed in dental injectors using a 27 mm gauged needle. During the first application the amount of i-PRF will be standardized as 4 mL and injected through intra-ligamental into the disto-buccal and disto-palatal side of the canine tooth (2 mL for each side) and at the time of second intervention i.e 8th week form the baseline intramucosal injection will be administered equidistant from the maxillary canine and second premolar, 2ml on buccal side and 2ml on palatal side) after anesthetizing the region with local anesthesia (2% Lignocaine).
: Distance of canine retraction in millimeters / month in different groups-control, single dose PRF and multiple doses of PRF.
Difference in root length of canine measured before and after canine retraction and compared amongst different groups
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