The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.
Subject has no diagnosed pulmonary conditions
Ability to read and understand English or Spanish
Subject has a diagnosis of pulmonary dysfunction made by a physician
No acute worsening of pulmonary function in the past 30 days
MRI is contraindicated based on responses to MRI screening questionnaire
Subject is pregnant or lactating
Subject does not fit into 129Xe vest coil used for MRI
Subject cannot hold his/her breath for 15-16 seconds
Single group
Hyperpolarized Xe129
DrugDuring MRI scanning, subject will inhale hyperpolarized xenon gas for a maximum of 16 seconds per scan, with a maximum of 4 MR scans + Calibration in a given imaging session.
RBC/Barrier Ratio
Ratio of xenon signal dissolved in RBCs to xenon signal dissolved in Barrier Tissues
ADC
Apparent Diffusion Coefficient of Xenon Gas in the lungs
Ventilation Defect Percentage
Percentage of the Lungs with ventilation signal below a threshold level
Click on the lead sponsor to view all of their trials.
Mario Castro, MD, MPH
Lead sponsor
University of Kansas Medical Center
Sponsor institution
