Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability

Stability of systolic and diastolic blood pressure (mmHg)

Will be measuring the number of participants that meet these criteria: 1. no sustained elevation of systolic blood pressure of more than 180 mmHg on more than two readings sustained for more than 20 minutes. 2. no sustained elevation of diastolic blood pressure of more that 120 mmHg on more than two reading sustained for more than 20 minutes. 3. No sustained reduction of systolic blood pressure of less than 70 mmHg on more than two readings sustained for more than 20 minutes. 4. No sustained reduction of diastolic blood pressure of less than 40 mmHg on more than two readings sustained for more than 20 minutes

Number of adverse changes in vital signs that require medical attention

Adverse change in vital signs, not otherwise meeting specified outcome criteria, that a treating provider feels requires medical intervention.

Number of changes in psychiatric symptoms that require medical intervention

Significant psychiatric symptoms within 24 hours post-dosing as determined by clinical staff to require medical intervention

Stability of pulse assessed by heart rate monitoring

no resting tachycardia for more than 20 minutes defined as heart rate greater than 110 bpm, or resting bradycardia for more than 20 minutes defined as less than 40 bpm.

Oxygen Percent Saturation

Stability of pulse oximetry. No reduction of percent saturation of less than 87% as assess by pulse oximetry on more than two readings sustained for more than 10 minutes.