SV2A in Older Adults

ConditionCannabis Use

Trial statusRecruiting

Trial phasePhase 1, Phase 2

Trial typeInterventional

Biological sexAll

Age50+

SponsorYale University

About this trial

The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using \[11C\]UCB-J PET imaging.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Able to provide informed consent

Male or female, aged ≥50 years

No history of significant medical or neurological disease

BMI ≤ 50

Disqualifiers

Women with a positive pregnancy test or women who are lactating

Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;

History of a bleeding disorder or are currently taking anticoagulants

Subjects who have donated blood within 8 weeks of the present study

Trial design

Design model

Parallel

Treatments tested in this trial

[11C]UCB-J PET
Drug
Single PET scan using the radioligand \[11C\]UCB-J

Treatment groups

24 Participants

are divided into 2 treatment groups

Group A: Cannabis using older adultsOther 1 intervention

Group B: Healthy controlsOther 1 intervention

Trial outcomes

Primary outcomes

Hippocampal synaptic density

Measure of synaptic density in the hippocampus

Time frame

1 month

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Yale University

Lead sponsor

National Institute on Drug Abuse (NIDA)

Collaborator

Source ClinicalTrials.gov

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