Health TrialsbyHealthPanel

taVNS Effects on Fear Ratings in Naturalistic Context

ConditionHealthy Participants
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-30
SponsorUniversity of Electronic Science and Technology of China

About this trial

During the fear rating task, 70 participants viewed a 600-second horror movie while continuously rating their subjective fear intensity (0-100 scale) every 0.51 seconds (1,170 total ratings). Functional near-infrared spectroscopy (fNIRS) data were simultaneously recorded using the NIRSIT LITE system to monitor cortical hemodynamic responses.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

Color blindness,

Current or regular substance or medication use

any current or history of medical or psychiatric disorders and contraindications for MRI

Trial design

Design model

Parallel

Treatments tested in this trial

  • transcutaneous auricular vagus nerve stimulation

    Device

    Ear clip electrodes attached to the left cymba conchae to target vagus nerve branches.

  • Sham condition

    Device

    Electrode placement attached on the left earlobe.

Treatment groups

70 Participants
are divided into 2 treatment groups
Group A: taVNS groupActive comparator 1 intervention
Group B: Sham groupSham comparator 1 intervention

Trial outcomes

Primary outcomes

1

Neural activity changes between groups

The differences in the activity of frontal regions between groups using fNIRS

Time frame
10 minutes
2

Fear ratings between groups

The differences in the fear ratings (0-100, from neutral to extremely fearful) between groups

Time frame
10 minutes
3

Functional connectivity witnin frontal regions between groups

The differences in the functional connectivity within frontal regions using fNIRS between groups

Time frame
10 minutes
4

The correlation between brain activity and behavioral ratings across groups

The correlation between brain activity and behavioral ratings across groups

Time frame
10 minutes

Secondary outcomes

1

Skin conductance response between groups

The differences in the skin conductance response during watching video between groups

Time frame
10 minutes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Electronic Science and Technology of China

Lead sponsor

Source ClinicalTrials.gov
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