Ultrasound-Guided Infraclvicular Block Using Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Upper Limb Orthopedic Surgery

Trial statusNot yet recruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-65
SponsorAssiut University

About this trial

this study is designed to evaluate and compare the efficacy of dexmedetomidine and nalbuphine as adjuvants to 0.5% bupivacaine in ultrasound-guided infraclavicular brachial plexus block for patients undergoing elective upper limb orthopedic surgeries on the duration of analgesia.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Nalbuphine

    Drug

    Nalbuphine will be added to .5% bupivacaine as an adjuvant in infraclavicular nerve block

  • Dexmedetomidine

    Drug

    Dexmedetomidine will be added to .5% bupivacaine as an adjuvant in infraclavicular nerve block

Treatment groups

66 Participants
are divided into 2 treatment groups
Group A: nalbuphine groupActive comparator 1 intervention
Group B: Dexmedetomidine groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Our primary outcome of this study will be: Duration of Analgesia.

Definition: The time interval (in minutes) between the completion of the infraclavicular block injection and the first request for rescue analgesia (VAS ≥ 3). Scale: Visual Analog Scale (VAS) Scale Title: Visual Analog Scale for Pain (VAS) Minimum Value: 0 (no pain) Maximum Value: 10 (worst possible pain) Interpretation: Higher VAS scores indicate worse pain, and a score of ≥ 3 indicates the need for rescue analgesia.

Time frame
till 24 hour postoperative

Secondary outcomes

1

Onset time of sensory and motor block

Time frame
till 20 minute after the block
2

Duration of sensory and motor block

Time frame
20 minute after the block
3

Time to first rescue analgesic request

Time frame
till 24 hour postoperative
4

Heart rate (HR)

Time frame
till 24 hour postoperative

Other outcomes

Sponsors and contacts

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