Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

ConditionRespiratory Disorders

Trial statusRecruiting

Trial phasePhase 1, Phase 2

Trial typeInterventional

Biological sexAll

Age18+

SponsorChildren's Hospital Medical Center, Cincinnati

About this trial

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through MRI.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adults ages 18 years and older

Participant must be able to hold their breath for up to 16 seconds

Disqualifiers

History of heart defect

Pregnancy or positive pregnancy test

History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month.

Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week.

Trial design

Design model

Single group

Treatments tested in this trial

Hyperpolarized 129 Xenon
Drug
During the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans
MRI
Device

Treatment groups

100 Participants

are divided into 1 treatment group

Group A: Hyperpolarized 129 XenonExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRI

quantify the measurement agreement between the ventilated volume of healthy lungs predicted via 129 Xe MRI and the ventilated volume of the pleural cavity predicted via proton MRI

Time frame

Day 1

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Children's Hospital Medical Center, Cincinnati

Lead sponsor

Source ClinicalTrials.gov

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