The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.
Ages 6 and up
Participant must be able to hold breath for up to 16 seconds
History of heart defect
Pregnancy or positive pregnancy test
History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month
Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week
Single group
Hyperpolarized 129 Xenon
DrugDuring the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans
Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRI
quantify the measurement agreement between the ventilated volume of healthy lungs predicted via 129 Xe MRI and the ventilated volume of the pleural cavity predicted via proton MRI
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