VG2025 is a Recombinant Human IL12/15 Dual-Regulated Oncolytic HSV-1 Injection. Currently, one phase I dose escalation safety study has been completed in China and the United States respectively, both demonstrating excellent safety profiles with no dose-limiting toxicities (DLTs) observed and no maximum tolerated dose (MTD) identified. Moreover, it has shown preliminary efficacy in treating advanced tumors. Considering the actual clinical needs and the volume of intratumoral administration, a more appropriate recommended phase 2 dose (RP2D) level has been selected for the phase II clinical trial.
Signed written informed consent form.
Age 18 to 75 years (inclusive), male or female.
Histologically or cytologically confirmed advanced intrahepatic cholangiocarcinoma.
Eligible participants of childbearing participants(male and female) must agree to use a reliable method of contraception during the trial and for at least 90 days after dosing; females of childbearing potential must have a negative blood pregnancy test 7 days before enrollment.
Participants who have received other unlisted drugs clinical trial treatment 4 weeks before the first dose of the study drug.
Participants who underwent major organ surgery (excluding needle biopsy) or had significant trauma 4 weeks before the first dose of the study drug.
In the herpes simplex virus recurrence and infection period, and there are corresponding clinical manifestations, such as oral herpes labialis, herpetic keratitis, herpetic dermatitis, genital herpes and so on.
Other active uncontrolled infection.
Single group
VG2025
DrugRecommended Phase II Dose, Intratumoral Injection, Q4W
ORR
Objective response rate (ORR)
DCR
Disease control rate (DCR)
PFS
Progression-free survival (PFS)
OS
Overall Survival (OS)
Correlation between VG2025 efficacy and CEA levels
Preliminary analysis of the correlation between the efficacy of VG2025 and peripheral blood carcinoembryonic antigen (CEA) levels
Immune-related indicators
Peripheral blood lymphocyte subsets, plasma cytokines, T cell immunity, and other immune-related indicators
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