This study is a single-center, longitudinal study and will be conducted at the Institute for Neurodegenerative (INDD) Site in New Haven, CT. This study aims to recruit participants from the ongoing Parkinson's Progression Markers Initiative AV-133 Prodromal Imaging sub study \[PPMI 015\] to obtain a second comparison imaging scan. In addition to being imaged with the standard Positron Emission Tomography (PET) camera after the \[18F\]AV133 injection in the PPMI 015 sub study, participants agreeing to a second scan will be imaged with the NeuroEXPLORER (NX) PET camera per this protocol.
This study will enroll approximately 25 participants at the INDD site. The dual PET scans will be completed at baseline, 1-and 2- years follow up. Participants may be asked to undergo further longitudinal scans based on the acquired study data.
All participants will have longitudinal clinical, biomarker, and genetic data for correlation analyses to imaging data from the PPMI Clinical study.
Prodromal participant enrolled in the PPMI 015 sub study.
Able to provide consent.
None
Single group
[18F] AV-133 PET Imaging
DrugThe study will compare the performance of \[18F\]AV133 on both NX and standard PET camera in study participants enrolled at the INDD site in PPMI 015.
Comparison of tracer uptake between two camera using Standardized Uptake Value ratio
To compare \[18F\]AV133 Standardized Uptake Value Ratio (SUVR) in striatal regions and additional relevant regions for images acquired with NX compared to Siemens Biograph in all participants
Longitudinal comparison of quantitative signals (SUVR) between two PET cameras
To compare the longitudinal regional change in \[18F\]AV133 SUVR in images acquired with NX PET and Siemens Biograph PET
Correlation of AV133 longitudinal change to clinical motor change
Correlation between longitudinal change in \[18F\]AV133 with NX derived SUVR in different brain regions and change in MDS-UPDRS score reported as correlation coefficient.
Correlation of AV133 longitudinal change to clinical cognitive change
Correlation between longitudinal change in \[18F\]AV133 with NX derived SUVR in different brain regions and change in Montreal Cognitive Assessment (MoCA) score reported as correlation coefficient.
Correlation of AV133 Longitudinal change to CSF biomarker
Correlation between longitudinal change in \[18F\]AV133 with NX derived SUVR in different brain regions and change in cerebrospinal fluid (CSF)- seed amplification assay (SAA) level reported as correlation coefficient.
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