The incidence of breast reconstruction failure after conventional photon radiotherapy for breast cancer is about 18.7%. At present, there is limited data on proton radiotherapy for post operative breast cancer with implantation reconstruction. Proton radiotherapy for breast cancer can significantly reduce the radiation dose of the ipsilateral heart and lung, thereby reducing the incidence of cardiac events and radiation pneumonia. This study is aimed at the study of adjuvant hypofractionated intensity-modulated proton radiotherapy for post operative breast cancer with implantation reconstruction. It can provide an ideal treatment option for such patients to effectively protect the heart and lungs without increasing the failure rate of breast reconstruction after adjuvant radiotherapy.
1: Patients with pathologically confirmed breast cancer
1: No pathological confirmation；
Single group
adjuvant hypofractionated intensity-modulated proton radiotherapy
RadiationCTV1: chest wall ± regional lymph drainage area, 40.05Gy (RBE) in 15 fractions with proton radiotherapy;
the failure rate of breast reconstruction after hypofractionated proton radiotherapy
Reoperation
Acute and late toxicities
Treatment related toxicity assessed by CTCAE v4.03
Tumor local control rate, overall survival rate and progression free survival rate
The Ipsilateral breast and regional lymph nodes recurrence, death and progression
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