This study is a multicenter study to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of treatment with SNH-119014 in adult participants with non-transfusion-dependent thalassemia. 30 participants with non-transfusion-dependent thalassemia were enrolled.
Male or Female;
Documented diagnosis of thalassemia;
Non-transfusion-dependent;
Hb concentration ≤10.0 grams per deciliter (g/dL) during the screening period;
Hemoglobin S forms of thalassemia;
History of Congestive Heart Failure Within 6 months prior to signed informed consent;
Myocardial Infarction/unstable angina Within 6 months prior to signed informed consent;
Deep Vein Thrombosis/stroke/thromboembolic events Within 6 months prior to signed informed consent;
Parallel
SNH-119014 dose 1
DrugStudy Drug
SNH-119014 dose 2
DrugStudy Drug
Placebo
DrugPlacebo
Safety evaluation
The incidence of Abnormal Laboratory Values, Clinically Significant Physical Examination Findings, vital signs, electrocardiogram (ECG) and/or Adverse Events
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