Clinical trial to assess the effect of microdroplet hyaluronic acid filler to the cheek skin (SKINVIVE™, JUVÉDERM®, Irvine, CA) on skin quality in patients undergoing medical weight loss with GLP-1 therapy.
Adult women aged 25-50 years.
Fitzpatrick skin types I-VI.
Current treatment with a stable dose of GLP-1 agonist medication for at least the last 6 months, for 16 of the enrolled subjects. Remaining 8 subjects should not be taking or have a history of taking a GLP-1 agonist therapy in the last year.
Presence of moderate skin changes (as defined by Modified Griffiths' Scale, with an average score of 4-6) in the following criteria: skin radiance/brightness, skin elasticity, tone evenness, skin firmness, fine lines, global wrinkles, and skin smoothness (tactile and visual).
The presence of severe facial skin aging (as defined by Modified Griffiths' Scale, with an average score of 7-9) or minimal facial skin aging (as defined by Modified Griffiths' Scale, with an average score of 0-3).
Females who are pregnant, planning a pregnancy, or currently breast feeding during the study.
Any uncontrolled systemic disease.
History of autoimmune connective tissue disease.
Parallel
Skinvive
Device16 GLP1 subjects treated with Skinvive to their cheeks for skin quality will be compared to 8 NON-GLP1 subjects treated with Skinvive for skin quality.
Global Fine Lines
Score 0 no fine lines thru 9 numerous, many fine lines
Overall Hyperpigmentation
Score 0= no hyperpigmentation thru 9= significant hyperpigmentation
Skin Tone Evenness
Score 0= Very even tone thru Score 9= Uneven, discolored appearance (brown and/or red colors)
Skin Firmness
Score 0= Firm, tight feeling skin thru Score 9= Loose, lax feeling skin
Physical Global Aesthetic Improvement Scale
Assess improvement of Abdominal skin laxity: Much Improved 2 Improved 1 No Change 0 Worse -1 Much Worse -2
Subject Global Aesthetic Improvement Scale
Assess improvement of Abdominal skin laxity: Much Improved 2 Improved 1 No Change 0 Worse -1 Much Worse -2
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
