Health TrialsbyHealthPanel

Cannabis' Impact on Alcohol Consumption

ConditionsAlcohol DrinkingCannabis UseCannabisAlcohol Use Disorder
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age21-50
SponsorBrown University

About this trial

This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which participants choose either to drink or receive monetary reinforcement for drinks not consumed. Cannabis will be administered simultaneously with an alcohol-priming dose or alcohol placebo.

The study will enroll up to 350 nontreatment-seeking heavy episodic alcohol drinkers who use cannabis weekly.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age 21 to 50

English-speaking

cannabis smoking in past two months

heavy drinking in past two months

Disqualifiers

positive pregnancy test

nursing

positive urine toxicology screen for drugs other than cannabis

interest to quit or receive treatment for cannabis or alcohol use

Trial design

Design model

Factorial

Treatments tested in this trial

  • THC-dominant cannabis

    Drug

    Smoked cannabis with 9.53% THC and 0.09% CBD

  • CBD-dominant cannabis

    Drug

    Smoked cannabis with 0.35% THC and 11.27% CBD

  • Cannabis placebo

    Drug

    Smoked placebo cannabis plant material

  • Alcohol

    Drug

    Drink containing 0.3 g/kg of alcohol

  • Alcohol placebo

    Drug

    Placebo beverage contains only juice and a negligible trace of alcohol for masking

Treatment groups

350 Participants
are divided into 5 treatment groups
Group A: THC-dominant cannabis doseExperimental treatment 2 interventions
Group B: CBD-dominant cannabis doseExperimental treatment 2 interventions
Group C: PlaceboPlacebo comparator 2 interventions
Group D: Alcohol priming doseExperimental treatment 3 interventions
Group E: Alcohol placebo dosePlacebo comparator 3 interventions

Trial outcomes

Primary outcomes

1

ml of alcohol consumed

ml of alcohol consumed during the alcohol choice task

Time frame
post-smoking during two-hours of the alcohol choice task

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Brown University

Lead sponsor

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Collaborator

Source ClinicalTrials.gov
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