Clinical Study of TJ0113 Capsule in the Treatment of Patients With Sarcopenia

Any medical condition that may interfere with adequate participation in the trial, including but not limited to the following: a history of epilepsy or complications, a history of hemolytic anemia, pulmonary embolism, or malignant tumors, or a positive tumor marker test result during the screening period that is assessed by the investigator as clinically significant;

New York Heart Association (NYHA) Class III or above congestive heart failure, unstable angina pectoris, acute myocardial infarction, hemorrhagic stroke, ischemic stroke (including transient ischemic attack) occurring within 6 months prior to screening; or Within 6 months prior to screening, undergone percutaneous coronary intervention, coronary artery bypass grafting, or cardiac valve repair/replacement; or at the time of screening, the presence of ventricular tachycardia, ventricular fibrillation, polymorphic ventricular tachycardia, etc., as judged by the investigator that may be life-threatening or lead to hemodynamic instability arrhythmia;

Personal or family history of long QT syndrome, family history of sudden death before the age of 40 in first-degree relatives (parents, children, and siblings); and/or personal history of unexplained syncope within 1 year prior to screening; and/or based on resting ECG results at screening: QT interval corrected for heart rate using Fridericia's formula, QTcF > 450 ms (males), QTcF > 470 ms (females) [Fridericia's formula: QTc = QT/(RR0.33), where RR represents the standard heart rate value, calculated as 60 divided by heart rate];

Presence of uncontrolled hypertension at screening, defined as systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg (confirmed before randomization);