About this trial
For investigators' current experimental clinical trial, patients are given 4 injections of ipilimumab, given 3 weeks apart x 4 injections with or without cytokine-induced killer therapy. Investigators propose to test this dual therapy in patients with melanoma who have known stage I, metastatic melanoma. Investigators hypothesize that this form of combinatorial immunotherapy will result in tumor stabilization or shrinkage, significant prolongation of progression-free, disease-free or overall survival compared to the use of ipilimumab alone
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Histological diagnosis of melanoma. AJCC Stage IV (any T, any N, M1), metastatic, progressive, refractory, melanoma.
Disqualifiers
Age <18-years-old. Active CNS metastases or carcinomatous meningitis. Patients with CNS lesions that have been treated and who have no evidence of progression in the brain on CT/MRI for ≥1 month are eligible. Pregnant or nursing women due to the unknown effects of immunization on the developing fetus or newborn infant.
Trial design
Parallel
Treatments tested in this trial
Cytokine-induced killer cells
Biological/VaccineCIK cells are transferred every 3 months for 1 year.
Ipilimumab
DrugIpilimumab are delivered every 3 weeks for one year
Treatment groups
Trial outcomes
Primary outcomes
Overall survival (OS)
Progression Free Survival (PFS)
Locations
Sponsors and contacts
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This trial is not recruiting at the moment. You can still explore other options: