interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT
All subjects with intermediate AMD diagnosis in one or both eyes will be considered, regardless the severity stage and subtype of disease in the other eye.
Patient previously taking high dose Atorvastatin 80 mg
Patients previously taking other statins than high dose atorvastatin, in whom primary care provider (PCP) feels cannot be safely moved to high dose atorvastatin or those in which high dose atorvastatin is deemed contraindicated by PCP
Patients with known adverse reaction to statins
Patients with severe renal disease or multiple comorbidities
Single group
Atorvastatin 80mg
DrugPatient will be receiving 80mg of Atorvastatin, if they are able to tolerate it from the start to the end of the study.
Change in Dark Adaptation recovery time measured by change in Rod Intercept time (RIT)
Determine weather improvement in dark adaptation recovery time or rod intercept time (RIT) can be used as an early indicator of positive response to high dose statin therapy for intermediate AMD patients
Change in drusen volume measured by Spectral Domain OCT
To measure and quantify improvement or positive response to high dose statin therapy in patients with intermediate AMD using drusen volume measured by SDOCT
To correlate visual functions of dark adaption with change in drusen volume
Patient will have Dark Adaptation testing performed to check change in vision function with changes in drusen volume.
To correlate Best Corrected Visual Acuity and retinal structural evaluation of study patients
Patient will have Best Corrected visual acuity, testing performed to check changes in vision function
To correlate change in contrast sensitivity and retinal structural evaluation of study patients
Patient will have quantitative contrast sensitivity function testing performed to check change in vision function with changes in drusen volume.
To correlate change in microperimetry visual functional and retinal structural evaluation of study patients
Patient will have microperimetry function testing performed to check change in this vision function with changes in drusen volume
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