"Dexa vs Dexmedetomidine With Bupivacaine in TAP Block for Laparotomy Analgesia

ConditionsPain, Postoperative Opioid Use Laparotomy

Trial statusRecruiting

Trial phasePhase 2, Phase 3

Trial typeInterventional

Biological sexAll

Age25-65

SponsorSahiwal medical college sahiwal

About this trial

Transversus abdominis plane block is a regional anesthetic technique which blocks the abdominal neural afferents by introducing local anesthetic into the neuro-fascial plane between the internal oblique and the transversus abdominis muscle and gives analgesia from the skin to parietal peritoneum. There are studies showing evidence of improved post operative analgesia with addition of adjuvants such as dexmedetomidine or dexamethasone in comparison with plane local anesthesia in terms of time to rescue analgesia and the overall quantity of analgesic used post operatively.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients undergoing laparotomy.

Patients aged 25 to 65 years.

Both genders.

Patients with ASA Class I, II.

Disqualifiers

Patients who do not give consent.

Patients with Comorbidities like DM, HTN, CKD, CLD.

Patients with bleeding disorders.

Infection at site of injection.

Trial design

Design model

Parallel

Treatments tested in this trial

Bupivacaine Hcl 0.25% Inj_#1
Drug
At the end of the surgery, bilateral Ultrasound (U/S) guided TAP block will be performed using ultrasound machine. The patient will be in supine position and a high frequency linear probe will be placed transverse to abdominal wall between the costal margin and iliac crest at mid axillary line. The needle will be introduced in plane of the ultrasound probe directly under the probe and advanced until it reaches the plane between the internal oblique and transverse abdominis muscles. Upon reaching the plane and after negative aspiration test for blood, 2ml of saline will be injected to confirm correct needle position, after which the patient will receive the TAP block as per the group allocation.
Bupivacaine Hcl 0.25% Inj_#2
Drug
At the end of the surgery, bilateral Ultrasound (U/S) guided TAP block will be performed in both groups using ultrasound machine. The patient will be in supine position and a high frequency linear probe will be placed transverse to abdominal wall between the costal margin and iliac crest at mid axillary line. The needle will be introduced in plane of the ultrasound probe directly under the probe and advanced until it reaches the plane between the internal oblique and transverse abdominis muscles. Upon reaching the plane and after negative aspiration test for blood, 2ml of saline will be injected to confirm correct needle position, after which the patient will receive the TAP block as per the group allocation.

Treatment groups

96 Participants

are divided into 2 treatment groups

Group A: GROUP AOther 1 intervention

Group B: GROUP BOther 1 intervention

Trial outcomes

Primary outcomes

postoperative pain

Duration of postop analgesia

Time frame

24 hours

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sahiwal medical college sahiwal

Lead sponsor

Source ClinicalTrials.gov

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