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Effect of MgSO4 Pretreatment on Muscle Relaxation

ConditionMuscle Relaxation
Trial statusRecruiting
Trial phasePhase 2, Phase 3
Trial typeInterventional
Biological sexAll
Age18-60
SponsorAssiut University

About this trial

In this study, the effect of magnesium sulphate on the onset and duration of intense and moderate cis-atracurium induced neuromuscular blocking and on the period of no response to nerve stimulation will be evaluated in patients who will recieve magnesium sulphate (intervention group) and patients who will not recieve magnesium sulphate (comparator group).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age group 18-60 years old

Both genders

Patients who will be scheduled to undergo elective otorhinolaryngological surgery.

Patients with BMI between 18.5 and 24.9 Kg/m2.

Disqualifiers

Patients who are less than 18 years old or more than 60 years old.

Patients on medications that interfered with muscle activity.

Allergy to medications used in this study.

Pregnancy or suspected pregnancy.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Magnesium Sulphate

    Drug

    A magnesium sulphate infusion (60 mg kg-1, total volume 100 ml, infusion rate 10 ml min-1) will be administered to patients 10 min. before induction of anesthesia.

  • Saline

    Drug

    The patients will be pretreated with an intravenous 0.9% saline infusion (total volume 100 ml, infusion rate 10 ml min-1) 10 min before induction of anesthesia.

Treatment groups

100 Participants
are divided into 2 treatment groups
Group A: MgSo4Active comparator 1 intervention
Group B: Saline PlaceboPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

The duration of the period of no response.

The effect of pretreatment with magnesium sulphate on the duration of the period of no response will be measured with the TOF-Watch SX (Organon Ireland Ltd, Dublin, Ireland). The ulnar nerve near the wrist will be stimulated and the activity of the adductor pollicis (thumb) muscle will be recorded.

Time frame
Intraoperative.

Secondary outcomes

1

The duration of intense neuromuscular block (minutes)

The effect of pretreatment with magnesium sulphate on the duration of the intense neuromuscular block in minutes will be measured with the TOF-Watch SX (Organon Ireland Ltd, Dublin, Ireland). The ulnar nerve near the wrist will be stimulated and the activity of the adductor pollicis (thumb) muscle will be recorded.

Time frame
Intraoperative
2

The duration of deep neuromuscular block

The effect of pretreatment with magnesium sulphate on the duration of the deep neuromuscular block in minutes will be measured with the TOF-Watch SX (Organon Ireland Ltd, Dublin, Ireland). The ulnar nerve near the wrist will be stimulated and the activity of the adductor pollicis (thumb) muscle will be recorded.

Time frame
Intraoperative.

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov
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