Based on the nutritional factor prediction model, the individualized nutritional management of patients with umbilical cord blood transplantation (UCBT) was carried out to observe the impact on the survival efficacy of patients.
Age 18-65 years old, conscious, with language communication skills;
UCBT patients to be performed;
Major organs without serious dysfunction;
The participants agreed to participate in the study and signed the informed consent form.
Age < 18 years old or > 65 years old or with cognitive impairment can not complete this survey;
Failure or recurrence of transplantation;
Combined with severe other organ system diseases (such as severe cardiac insufficiency, autoimmune disease, active infection, severe trauma) ;
Patients who have difficulty collecting data to complete the nutritional intervention;
Single group
Individualized nutrition intervention
Procedure/SurgeryAfter the patients were enrolled, they were given nutritional assessment by full-time clinical nutritionist and designed individualized nutritional management program, which included: Nutritional Assessment once a week for 4 weeks after Transplantation + 30 days, and nutritional assessment once a week for 4 weeks after Transplantation + 60 days, nutritional assessment every 2 weeks for 8 weeks; nutritional assessment every 4 weeks for 1 year after Transplantation + 120 days after transplantation; nutritional assessment during hospitalization in the ward and after discharge from the hospital, they were followed up in the nutrition counseling clinic or by telephone. The total energy intake was 25-35 kcal/kg/d and the protein intake was 1.2-1.5 g/kg/d. According to the"Five-step nutritional treatment principle", individual nutritional prescriptions were designed by clinical nutritionists.
The body mass index
Body Mass Index (BMI) is defined as a person's weight in kilograms divided by the square of their height in meters (kg/m²).
The calf circumference
The calf circumference (cm)
The thickness of skinfold
thickness of skinfold (mm)
Grip strength
The grip strength (kg)
Incidence of complications
Incidence of acute graft-versus-host disease (GVHD), incidence of chronic GVHD, incidence of oral mucositis and rate of infection.
Overall survival (OS)
OS was calculated from the date of transplantation to death or last follow-up.
Disease-free survival (DFS)
DFS was defined as the time from transplantation to relapse or death from any cause.
The cumulative incidence of relapse (CIR)
Relapse and death were considered to be competing events when calculating CIR and NRM .
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