The objective of this study is to investigate "clinically" the effectiveness of Glycyrrhizin based intracanal medication compared to the commonly used intracanal medicaments (calcium hydroxide Ca(OH)2 and Ledermix) on the levels of bacteria and inflammatory cytokines in root canals and periradicular tissues of teeth with apical periodontitis.
Single-rooted with pulp necrosis and apical periodontitis.
Receiving antibiotic treatment within the preceding 3 months.
Reporting systemic disease.
Teeth that could not be isolated with rubber dam.
Teeth with periodontal pockets deeper than 3 mm.
Crossover
Calcium Hydroxide
DrugIntracanal medication
Leddermix
DrugIntracanal medication
Glycirrhizin
DrugIntracanal medication
counting the number of colonies forming units of bacterial cells
Microbiology cell culturing (manual counting technique to the bacterial cells)
using enzyme-linked immunosorbent assay (ELISA test) to measure the amount of Inflammatory Cytokines (TNF-α), (IL-1β) and (PG2)
ELISA test to measure the amount of tumor necrotizing factor (TNF-α), interleukin 1β(IL-1β) and prostaglandin E2 (PG2)
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