Health TrialsbyHealthPanel

Evaluation of CT-XPI

ConditionsCT ScanComputed Tomography
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Wisconsin, Madison

About this trial

The goal of this clinical trial is to learn if a new computed tomography (CT) lung perfusion imaging method is as effective as standard of care (SOC) CT imaging. The main question it aims to answer is:

* Does the new contrast-free method provide more information about lung perfusion than SOC?

Participants will undergo a 30 minute chest CT.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18 years or older

Able to sign and date the informed consent form

Will undergo a clinically-indicated CT exam of the head, neck, chest, abdomen, pelvis, or extremities

Disqualifiers

Pregnant or lactating

In need of urgent or emergent care

Have any conditions that, in the opinion of the PI or designee, would interfere with the evaluation of the results or constitute a health hazard for the participant

Trial design

Design model

Single group

Treatments tested in this trial

  • CT scan

    Diagnostic test

    Dynamic contrast-free chest CT scan

Treatment groups

30 Participants
are divided into 1 treatment group
Group A: CT scanExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Lung x-ray pulsatility index (XPI)

XPI, a representative of lung perfusion, will be measured using CT images. The dynamic x-ray attenuation from each pixel is analyzed using spectral analysis.

Time frame
30 minutes
2

Magnitude of XPI

Measured as a number, this corresponds to the magnitude of the relative change of signal.

Time frame
30 minutes
3

Presence of XPI

This will be evaluated quantitatively using CNR (contrast to noise) measurements which uses a region of interest in the lungs and a region of interest outside of the lungs.

Time frame
30 minutes
4

Spatial distribution of XPI signal

This is a subjective evaluation, routinely done clinically with other modalities that measure lung perfusion. Researchers evaluate how homogenous (smooth) the signal is over the lungs and look for perfusion defects (areas with little or no XPI) which would indicate pathology.

Time frame
30 minutes

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Wisconsin, Madison

Lead sponsor

Source ClinicalTrials.gov
Apply now