Exploratory Single-arm, Single-center Adjuvant Treatment of Stage IIIB-IIIC Gastric Cancer With Combination of Palizumab and SOX Regimen

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorShanghai Minimally Invasive Surgery Center

About this trial

it is an an Exploratory Single-Arm, Single-Center Study of Pembrolizumab in Combination with SOX Regimen for Adjuvant Treatment of Stage IIIB-IIIC Gastric Cancer

Eligibility criteria

Qualifiers

Consistent with high-frequency microsatellite instability MSI-H

Consistent with high tumor mutation load TMB-H (≥10 mutations/megabases)

Hemoglobin ≥90g/L;

Absolute neutrophil count ≥1.5×109/ L;

Disqualifiers

Patients with severe hypertension and poor drug control;

Patients with difficulty in taking oral drugs due to dysphagia, complete or incomplete digestive tract obstruction, active gastrointestinal bleeding, perforation, etc.;

People who are known to be allergic to the ingredients in the test drug or have metabolic disorders;

Simultaneously participating in other tumor experimental drugs or being in other tumor clinical trials.

Trial design

Treatments tested in this trial

  • Pembrolizumab + SOX

Treatment groups

20 Participants
are divided into 1 treatment group