Objective: This study aimed to analyze the outcomes of post-infectious olfactory dysfunction treated with different doses of corticosteroids and specify factors related to the curative effect. Methods: The medical records of patients diagnosed with post-infectious olfactory dysfunction from January 2020 to december 2025 were reviewed. All patients were treated with different doses of oral corticosteroids for 12 days or they inhaled corticosteroids for 1 month.
The history of upper respiratory tract infection was confirmed, and the previous sense of smell was normal.
Other causes of olfactory disorder suggested by the history
Parallel
methylprednisolone
DrugThe patients were treated with three protocols: (1) oral methylprednisolone, 40 mg for 3 days, 20 mg for 3 days, and 8 mg for 6 days; (2) oral methylprednisolone, 20 mg for 3 days, 10 mg for 3 days, and 4 mg for 6 days. At the same time, all patients received olfactory training for 12 weeks as proposed by Hummel et al
budesonide atomization suspension
Drug(3) budesonide atomization suspension (AstraZeneca Trading Co., Ltd, AU.) inhaled through the nose atomized with an air compression atomizer for 4 weeks, 2 mg for the first 2 weeks and reduced to 1 mg for the last 2 weeks. At the same time, all patients received olfactory training for 12 weeks as proposed by Hummel et al
overall effective rate
A repeat T\&T subjective olfactory test will be performed after the treatment. Patients with normal sense of smell will be defined as cured; patients with average T\&T recognition threshold decreased by 1 point will be defined as improved; patients with average T\&T recognition threshold decreased by 2 points or more, which did not reach the normal range, will be defined as significantly improved; and patients with average T\&T recognition threshold decreased by 1 point, with or without falling, will be defined as invalid.
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