Intra-tumor Injection of Drug-eluting Microspheres With Multiple Drugs
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-99
SponsorSecond Affiliated Hospital of Guangzhou Medical University
About this trial
To study the safety and clinical effect of injection of drug-eluting microspheres with multiple chemodrug and/or protein drugs into advanced solid tumors.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Solid advanced malignant tumors
Age between18 and 99 years
Life expectancy is greater than three months
Disqualifiers
Benign tumor
Life expectancy is less than three months
Serious medical comorbidity
Others
Trial design
Design model
Parallel
Treatments tested in this trial
Injection of drug-eluting microspheres with multiple drugs into solid tumors
DrugUnder the guidance of CT, puncture fine needle was used to inject drug-eluting microspheres loading with multiple drugs into the tumor
Treatment groups
100 Participants
are divided into 3 treatment groupsGroup A: Group 1: DC-Beads loading with Chemodrug/IL2/PD1/CTLA4 antibodiesExperimental treatment 1 intervention
Group B: Group 2: DC-Beads loading with Chemodrug/IL2/PDL1/CTLA4 antibodiesExperimental treatment 1 intervention
Group C: Group 3: DC-Beads loading with Chemodrug/IL2/PD1/PDL1/CTLA4 antibodiesExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Assessing safety and treatment efficacy on intra-tumor injection of DEB for advanced tumors
Assessing incidence of side effects and primary clinical response of the intra-tumor injection of DEB in advanced solid cancers, including CR, PR, SD, and PD.
Time frame
up to 36 monthsSponsors and contacts
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Source ClinicalTrials.gov