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Naloxone for In-Hospital Cardiac Arrest

ConditionHeart Arrest
Trial statusNot yet recruiting
Trial phasePhase 2, Phase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorRegion Skane

About this trial

The goal of this clinical trial is to learn if the drug naloxone in addition to cardiopulmonary resuscitation improves outcomes of in-hospital cardiac arrets. The main questions it aims to answer are:

Does naloxone improve survival after the cardiac arrest? Does naloxone improve functional outcome in survivors of cardiac arrest? Does naloxone improve health related quality of life after the cardiac arrest? How common are adverse reactions to naloxone when administered during cardiopulmonary resuscitation.

Researchers will compare naloxone to a placebo (a look-alike substance that contains no drug) to see if naloxone works during cardiac arrest.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

In-Hospital Cardiac Arrest

Age ≥ 18 years

Received at least one dose of adrenaline during CPR

Disqualifiers

"Do-not-resuscitate"-order

Known/suspected pregnancy

Known objection by the patient to participate in the trial

Previous inclusion in the trial

Trial design

Design model

Parallel

Treatments tested in this trial

  • naloxone

    Drug

    2 mg naloxone administered intravenously or intraosseously

  • Placebo

    Drug

    0.9% saline administered intravenously or intraosseously

Treatment groups

850 Participants
are divided into 2 treatment groups
Group A: naloxoneActive comparator 1 intervention
Group B: placeboPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

30-day survival

proportion of patients alive

Time frame
30 days after the cardiac arrest

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Region Skane

Lead sponsor

Lund University

Collaborator

Clinical Studies Sweden - Forum South

Collaborator

Copenhagen Trial Unit, Center for Clinical Intervention Research

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: