Nurturing Exercise Routine for Greater Improvement in Zest and Energy on Enhertu
ConditionMetastatic Breast Cancer
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Utah
About this trial
The goal of this study is to test the efficacy of using a 12-week, home-based, unsupervised aerobic and resistance training exercise program for changes in cancer-related fatigue in patients with metastatic breast cancer who are receiving Enhertu.
Eligibility criteria
Qualifiers
Subject aged ≥ 18 years
Diagnosis of locally advanced/unresectable or metastatic breast cancer. Note: Patients with High-Risk HER-2 + breast cancer after completion of neoadjuvant chemotherapy requiring adjuvant Enhertu are allowed at the discretion of the treating physician.
Has received 3 or 4 cycles of Enhertu and is expected to continue treatment for at least 12 weeks. Note: HER-2 targeted systemic therapy (e.g. Trastuzumab and/or Pertuzumab) in conjunction with Enhertu is allowed.
Able and willing to participate in the interventional aerobic exercise and resistance exercises.
Disqualifiers
Structured is defined as time set aside in the subject's day to workout.
Resistance training is defined as exercises which use weights, bands, or body weight (e.g., squats or push-ups).
Moderate-intensity exercise is defined as activities where the subject can talk but not sing.
Aerobic exercise includes, but is not limited to, walking, swimming, cycling, running, rowing, hiking, and elliptical.
Trial design
Treatments tested in this trial
- Whole-body resistance training and aerobic exercise
Treatment groups
80 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov