ONE-P TMS First Responders

ConditionPTSD - Post Traumatic Stress Disorder

Trial statusNot yet recruiting

Trial phasePhase 2

Trial typeInterventional

Biological sexAll

Age19-60

SponsorFidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA

About this trial

The aim of this study is to examine the feasibility and tolerability of a one-day protocol of repetitive transcranial magnetic stimulation with D-cycloserine (DCS) as an augmentation strategy in first responders who have PTSD.

Eligibility criteria

Qualifiers

are outpatients between the ages of 19-60;

are voluntary and competent to consent;

are first responders (active, on leave or retired);

have DSM-5 diagnosis of PTSD with a CAPS for DSM-5 (CAPS-5) score ≥ 25;

Disqualifiers

have a Severe Substance Use Disorder (except tobacco) within the last three (3) months;

have a concomitant major unstable medical illness, cardiac pacemaker or implanted medication pump;

have active suicidal intent;

are pregnant;

Trial design

Treatments tested in this trial

D-Cycloserine (DCS)
Placebo
Intermittent Theta Burst Stimulation (iTBS)

Treatment groups

50 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA

Lead sponsor

University of British Columbia

Sponsor institution

Source ClinicalTrials.gov