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Palmitic Acid and Human Microvascular Function

ConditionsMicrovascular DysfunctionMicrovasculatureCardiovascular DiseasesCardiovascular Diseases (CVD)Microvascular HealthObesity and Overweight
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-40
SponsorMedical College of Wisconsin

About this trial

The goal of this study is to learn how a supplement Quercetin can affect microvascular function.

Participants will:

* give two blood draws of 5 mL each * have a camera placed under the tongue to take pictures of blood vessels * have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion

Researchers will compare blood vessel function of those who take estrogen supplements to those who do not.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Obesity (BMI>30)

Aged 18-40 years

English Speaking

Disqualifiers

BMI>60

Resting SBP ≥180 mmHg or DBP ≥ 110mmHg

Pregnancy or breastfeeding.

Prior history of myocardial infarction

Trial design

Design model

Parallel

Treatments tested in this trial

  • Quercetin (dietary supplement)

    Dietary supplement

    Quercetin will be provided to take one Quercetin per day for 30 days to look for differences in microvascular function.

  • Placebo

    Drug

    Subjects randomized to receive placebo will be administered a standard placebo sugar pill.

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: Use of oral quercetin to improve human microvascular functionExperimental treatment 1 intervention
Group B: PlaceboPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in blood vessel dilation

Peripheral microvascular dilation in response to acetylcholine, L-NAME, and sodium nitroprusside infusions will be measured using laser Doppler flowmetry with microdialysis.

Time frame
2 hours

Secondary outcomes

1

Change in Perfused Vessel Density

Total vessel density (TVD) will be calculated using the DeBacker Score manual analysis on all images that have a minimum microcirculation image quality score (MIQS) of 10. Perfused vessel density (PVD) will be calculated by multiplying total vessel density (TVD) x proportion of perfused vessels (PPV%).

Time frame
0.5 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Medical College of Wisconsin

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: