Positron Emission Tomography/Computed Tomography (PET/CT) Imaging in Patients Diagnosed With a Glioma
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorBarbara Ann Karmanos Cancer Institute
About this trial
The goal of this clinical trial is to evaluate Positron emission tomography/computed tomography (PET/CT) imaging with the radiotracer 1-(2-\[18F\]fluoroethyl)-l-tryptophan (\[18F\]FETrp) in patients diagnosed with a glioma. This study has 3 aims:
* to assess if the \[18F\]FETrp PET/CT can outperform Magnetic Resonance Imaging (MRI) by providing a better treatment target volume in newly diagnosed Stage 4 glioma patients * better differentiate tumor progression from radiation induced MRI changes in post treatment stage 4 gliomas * by giving a drug that can inhibit a pathway to allow objective assessment of treatment effects in low grade gliomas
Eligibility criteria
Qualifiers
Age =18 years.
Patient is able to lie in the PET/CT scanner for at least 60 minutes while undergoing scanning.
Patient is willing and able to review, understand, and provide written consent for the study procedures and indicates that they are aware of the investigational nature of this study.
Disqualifiers
Patients who are pregnant or lactating are excluded. Premenopausal women (defined per institutional guidelines) must have a negative pregnancy test (urine or serum) within 7 days of the PET scan.
Severe increased intracranial pressure, status epilepticus, or other severe or progressing clinical symptoms requiring urgent intervention in the opinion of the treating
Karnofsky performance score <60, as determined by one of the clinician co- investigators.
Histopathology/cytopathological diagnosis of a glioblastoma without a history of radiation.
Trial design
Treatments tested in this trial
- Minocycline 200mg/day
- [18F]FETrp PET/CT
Treatment groups
61 Participants
are divided into 3 treatment groupsSponsors and collaborators
Barbara Ann Karmanos Cancer Institute
Lead sponsor
Wayne State University
Collaborator
Source ClinicalTrials.gov