The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79.
Researchers will compare a placebo to the active medication.
Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.
Undergoing elective gynecological surgery by either an open abdominal or minimally invasive approach (to include both endoscopic and vaginal). Procedure must be performed under general anesthesia.
Pregnant,
Patients with gastrointestinal disease requiring ongoing medical management.
Prior gastrointestinal surgery with the exception of diagnostic procedures, appendectomy and cholecystectomy.
Patients with a history of H2 receptor blocker use, proton pump inhibitor use or other GERD specific therapy within 30 days of surgery.
Parallel
pantoprazole
DrugPantoprazole 40mg given the night before surgery, 2 hours prior to surgery, and the evening after surgery.
Placebo
DrugPlacebo given the night before surgery, 2 hours prior to surgery, and the evening after surgery.
Postoperative Nausea and Vomiting
Postoperative nausea and vomiting compared between two groups using Visual Analog Scale from 0-10. A score of 0 indicates no nausea and higher scores reflect progressively greater severity.
Time to Oral Intake
Measure the time from surgery until patients can tolerate oral intake.
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