Health Trials

Rutin and Vitamin C in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)

ConditionNAFLD
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-65
SponsorAin Shams University

About this trial

evaluate the combined effects of Rutin and Vitamin C versus Vitamin C alone on selected oxidative stress markers, inflammation, hepatic steatosis regression, and associated metabolic parameters in patients with MASLD

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Confirmed diagnosis of Metabolic-Associated Steatotic Liver Disease (MASLD).

Disqualifiers

HCV infection.

HBV infection.

Patients with a history of significant alcohol consumption.

Autoimmune hepatitis.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Rutin + Vitamin C

    Drug

    Type: Drug (Combination therapy) Details: Oral administration of two tablets containing 60 mg Rutin + 160 mg Vitamin C, taken three times daily for 12 weeks.

  • Vitamin C 500mg

    Drug

    Type: Drug (Single agent) Oral administration of Vitamin C 500 mg, taken twice daily for 12 weeks

  • Lifestyle Intervention

    Behavioral

    Mediterranean diet focusing on fruits, vegetables, whole grains, healthy fats, plus structured exercise program for 12 weeks.

Treatment groups

120 Participants
are divided into 3 treatment groups
Group A: Ruta C groupExperimental treatment 1 intervention
Group B: Vitamin C groupExperimental treatment 1 intervention
Group C: Control groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

• Change in tumor necrosis factor-alpha (TNF-α) levels from baseline to week 12.

Serum TNF-α, a key biomarker of inflammation in MASLD

Time frame
12 weeks

Secondary outcomes

1

• Change in serum malondialdehyde (MDA) levels from baseline to week 12.

Malondialdehyde (MDA) is a well-established biomarker of oxidative stress in MASLD, reflecting lipid peroxidation and liver injury.

Time frame
12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ain Shams University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: