Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-80
SponsorMedical University of South Carolina

About this trial

Smell dysfunction significantly impacts quality of life and safety, with limited effective treatments. This open-label study evaluates the preliminary efficacy of combining non-invasive trigeminal nerve stimulation (TNS) with standard smell training (ST) to improve olfactory function. Participants will complete 8 weeks of at-home treatment and attend three in-person visits for assessment. Improvements in smell, mood, sleep, and quality of life will be measured.

Eligibility criteria

Qualifiers

Age 18-80

Self-reported or medically documented smell loss

Treatment-seeking for their smell loss

Naïve to TNS

Disqualifiers

Medical Records not available to confirm eligibility

Documented/Suspected head injury (e.g. sport, accident, blast exposure)

Neurological disorder (e.g. epilepsy, neurodegenerative disorder)

Serious mental illness (e.g. schizophrenia, bipolar disorder)

Trial design

Treatments tested in this trial

  • Trigeminal Nerve Stimulation-enhanced Smell Training

Treatment groups

60 Participants
are divided into 1 treatment group