Substance Use in Pregnancy - Optimizing Retention in Treatment by Maximizing Opportunities for Management

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18+
SponsorWashington University School of Medicine

About this trial

Overdose is a national top-three leading cause of pregnancy-associated death, and maternal substance use disorder (SUD) accounts for an estimated $1.5 billion in healthcare spending each year. Treatment with medication and behavioral therapy lowers morbidity and overdose risk. However, studies have shown 55% to 80% of patients stop treatment within one year postpartum. Additionally, as a result of systemic inequities, historically marginalized patients are at greatest risk of overdose or death. We are conducting a study at WashU Medicine and University of Maryland, Baltimore clinics that offer prenatal care, addiction treatment, and extended postpartum support for patients facing the challenges of a SUD. Study participants will complete a structured screening and management of their social needs, and then will be randomly assigned to continue their usual care or to participate in a contingency management program, which provides incentives to continue treatment.

Eligibility criteria

Qualifiers

Confirmed viable intrauterine pregnancy at any gestational age; OR postpartum with at least six months remaining until 365 days after deliver

Diagnosis of SUD as defined by DSM-5 and/or as documented in the clinical record

18 years of age or older

Two or more positive domains in first screening for social drivers of health

Disqualifiers

Declining follow-up care at participating study site

Participated in R61 pilot study for CM

Requiring immediate hospitalization for unstable medical or psychiatric conditions making patient clinically unsuitable for research participation at the time of enrollment approach

Unable to participate in English

Trial design

Treatments tested in this trial

  • Contingency Management
  • Social Drivers of Health Screening

Treatment groups

245 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Washington University School of Medicine

Lead sponsor

University of Maryland, Baltimore

Collaborator