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Successive Doses of GnRH Agonist Versus Single Dose of GnRH Agonist to Trigger Ovulation in Hyper-responders

ConditionInfertility
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorBedaya Hospital

About this trial

The aim of this randomized controlled study is to compare the efficacy of three successive doses of a GnRH agonist ( administered 36 , 24 and 12 hours before oocyte retrieval ) with a single dose of a GnRH agonist ( administered 36 hours before oocyte retrieval ) in triggering ovulation in hyper-responders

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

GnRH antagonist IVF cycle

Hyper-responders to induction of ovulation

Disqualifiers

Hypogonadotrophic hypogonadism

Endometriosis

History of recurrent abortion

Trial design

Design model

Parallel

Treatments tested in this trial

  • Successive doses GnRH agonist

    Drug

    GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup. Two additional doses of triptorelin ( 0.1 mg / S.C ) are administered subcutaneously 12 and 24 hours after the first dose of GnRH agonist.

  • Single dose GnRH agonist

    Drug

    GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup.

Treatment groups

190 Participants
are divided into 2 treatment groups
Group A: Successive doses GnRH agonistExperimental treatment 1 intervention
Group B: Single dose GnRH agonistActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Metaphase-II oocytes rate

Number of MII oocyte/ number of cumulus oocyte complex

Time frame
Ten to fifteen days after starting ovarian stimulation

Secondary outcomes

1

Clinical pregnancy rate

Presence of intrauterine gestational sac detected by transvaginal ultrasound

Time frame
Five weeks after embryo transfer
2

Ongoing pregnancy Rate

Pregnancies continued beyond 20 weeks gestation

Time frame
Eighteen weeks after embryo transfer

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Bedaya Hospital

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: