Health TrialsbyHealthPanel

Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG Trigger

ConditionInfertility (IVF Patients)
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorBedaya Hospital

About this trial

The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol \[a single bolos of HCG combined with two successive doses of a GnRH agonist \] with HCG \[a single bolos administered 36 hours before oocyte retrieval \] in triggering ovulation in normo-responders undergoing ovarian stimulation using the antagonist protocol.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

GnRH antagonist IVF cycle

Normo-responders to induction of ovulation

Disqualifiers

Hypogonadotrophic hypogonadism

Endometriosis

History of recurrent abortion

Trial design

Design model

Parallel

Treatments tested in this trial

  • Modified dual trigger

    Drug

    HCG (10000 IU /IM) and triptorelin (0.2 mg/S.C) are administered 36 hours before ovum pickup . Moreover, 0.1mg of triptorelin is administered 24 h prior to ovum pick-up.

  • HCG

    Drug

    HCG (10000 IU/IM ) is administered 36 hours before ovum pickup.

Treatment groups

196 Participants
are divided into 2 treatment groups
Group A: Modified dual trigger groupExperimental treatment 1 intervention
Group B: HCG groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Metaphase-II oocytes rate

Number of MII oocyte/ number of cumulus oocyte complex

Time frame
Ten to fifteen days after starting ovarian stimulation

Secondary outcomes

1

Clinical pregnancy rate

Presence of intrauterine gestational sac detected by transvaginal ultrasound

Time frame
Five weeks after embryo transfer
2

Ongoing pregnancy Rate

Pregnancies continued beyond 20 weeks gestation

Time frame
Eighteen weeks after embryo transfer

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Bedaya Hospital

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: