A multicenter phase III clinical study evaluating the diagnostic performance and safety of PET for the deposition of Aβ plaques in the brain of participants with normal cognitive function, MCI and AD using \[18F\]Fluorbetazine injection.
None
Known allergy to [18F]Fluorbetazine injection or its excipients.
Presence of previously implanted metal devices that are incompatible with MRI examinations, including pacemakers, defibrillators, insulin pumps, cochlear implants, intraocular metal implants, nerve stimulators, or CNS aneurysm clips; or suffering from claustrophobia or intolerance to imaging procedures for other reasons.
Cognitive impairment caused by reasons other than Alzheimer's disease (AD).
More than 2 infarctions with a diameter greater than 2 cm in any part of the brain;