About this trial
This phase III trial compares the effect of adding radiation therapy to the usual maintenance therapy with adebrelimab versus adebrelimab alone in patients who have already received debrelimab plus chemotherapy for the treatment of extensive stage small cell lung cancer.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Aged 18-75 years, male or female;
Histologically or cytologically confirmed extensive stage small cell lung cancer (according to the Veterans Lung Administration Lung Study Group, VALG stage);
ECOG performance status score 0 ~ 1;
No prior line of systemic therapy for ES-SCLC;
Disqualifiers
Histologically or cytologically determined as a mixed pathological type with components such as non-small cell lung cancer;
Active or untreated CNS metastases detected by computed tomography (CT) or magnetic resonance imaging (MRI) during the screening period and previous imaging assessments;
Spinal cord compression that is not relieved by surgery and/or radiotherapy;
Clinically symptomatic third space effusion requiring repeated drainage within 2 weeks, such as pericardial effusion, pleural effusion, and abdominal effusion that are still uncontrollable by pumping or other treatments;
Trial design
Parallel
Treatments tested in this trial
Adebrelimab
DrugGiven:IV
Radiation Therapy
RadiationUndergo radiation therapy
Treatment groups
Trial outcomes
Primary outcomes
PFS
OS
Secondary outcomes
ORR
DoR
DCR
6m and 1-year PFS rate
Other outcomes
To detect biomarkers associated with efficacy
Locations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Jinming Yu
Lead sponsor
Shandong Cancer Hospital and Institute
Sponsor institution
This trial is not recruiting at the moment. You can still explore other options: