Cardiovascular Protection After Preeclampsia With Enalapril

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexFemale
Age18+
SponsorWomen and Infants Hospital of Rhode Island

About this trial

The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Postpartum individuals

≥18 years old

Hypertensive disorder of pregnancy

Enrolled in Women and Infants Hospital Hypertension Equity remote monitoring program.

Disqualifiers

Maternal cardiac disease

Individuals with pre-pregnancy hypertension or diabetes

Allergy or contraindication to enalapril

Trial design

Design model

Parallel

Treatments tested in this trial

  • Enalapril

    Drug

    First-line anti-hypertensive treatment with enalapril

  • Standard treatment

    Other intervention

    First-line anti-hypertensive treatment per standard of care

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: EnalaprilExperimental treatment 1 intervention
Group B: Standard treatmentActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Feasibility of enrollment

Proportion of approached individuals who are enrolled

Time frame
4 months
2

Feasibility of retention

Retention of participants to 4 months postpartum

Time frame
4 months

Secondary outcomes

1

Blood pressure

Systolic and diastolic blood pressure

Time frame
4 months
2

Blood pressure

Systolic and diastolic blood pressure

Time frame
6 weeks
3

Mean home blood pressure

Mean systolic and diastolic blood pressure

Time frame
6 weeks
4

Mean arterial pressure

Mean arterial blood pressure

Time frame
4 months

Other outcomes

Sponsors and contacts

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