Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age1-2
SponsorCombined Military Hospital, Pakistan
About this trial
The goal of this clinical trial is to compare the efficacy of hypertonic saline nebulization with adrenaline nebulization in the treatment of acute bronchiolitis in children. Main aim is to evaluate the following in both group of patients
1. Improvement in Wood-Downes clinical score (WDF score) in bronchiolitis 2. Length of Hospitalization
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
All children admitted in PICU with acute bronchiolitis
Disqualifiers
children with co-exiting illnesses like
Congenital Heart Disease
Immunodeficiency
other Infectious disease like Meningitis, encephalitis, Pneumonia, TORCH
Trial design
Design model
Parallel
Treatments tested in this trial
Hypertonic Saline Solution, 1 Ml
DrugDilute 0.3 ml hypertonic saline with 3 ml normal saline for nebulization
Adrenaline
Drugdilute 0.3 ml adrenaline with 3 ml normal saline for nebulization
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: Hypertonic saline nebulization groupActive comparator 1 intervention
Group B: Adrenaline nebulization groupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Wood-Downes-Ferres clinical score calculation
A score of 0-3 mild, 4-6 moderately ill, \>6 severely ill
Time frame
at 24 and 48 hours of treatmentSecondary outcomes
1
total length of hospitalization
less than 1 week, more than 1 week,
Time frame
less than 7 days, 7-10 days, 10-14 daysSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov