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Comparison of Intranasal Ketorolac and Intranasal Ketamine in Digital Nerve Block Pain

ConditionsPainDigital Block
Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-65
SponsorTehran University of Medical Sciences

About this trial

This study aims to compare the analgesic effectiveness and side effects of intranasal ketorolac versus intranasal ketamine for reducing pain prior to digital nerve block procedures in patients with finger injuries in emergency department.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age: 18-65 years

Weight > 50 kg

Requires digital nerve block

Able to provide informed consent

Disqualifiers

Active peptic ulcer disease (PUD)

History of hypersensitivity to NSAIDs

Pregnancy and breastfeeding

Renal failure

Trial design

Design model

Parallel

Treatments tested in this trial

  • Intranasal Ketorolac Tromethamine

    Drug

    30 mg ketorolac will be administered intranasally using mucosal atomizer. Half dose (0.5 cc) in each nostril, Given 5 minutes before digital nerve block.

  • Intranasal ketamine

    Drug

    50 mg ketamine will be administered intranasally using mucosal atomizer,. Half dose (0.5cc) in each nostril, Given 5 minutes before digital nerve block

Treatment groups

64 Participants
are divided into 2 treatment groups
Group A: Intranasal KetamineActive comparator 1 intervention
Group B: Intranasal Ketorolac TromethamineExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Block pain intensity

The numerical rating score (NRS) will be used for the study. The NRS ranges from 0 (no pain) to 10 (very severe pain). The higher the pain scores the higher the pain severity. The pain severity will be asked from the patients.

Time frame
Immediately after block

Secondary outcomes

1

Nasal irritation

We will ask the patients about this outcome use a 3-level Likert-like scale.

Time frame
60 minutes after the block
2

Side effects

The patients will be assessed every 15 minutes for this outcome.

Time frame
From the drug administration to 60 minutes after the block
3

Patient satisfaction score

The patients will be asked about their satisfaction using a 3-level Likert like scale.

Time frame
60 minutes after the drug administration.

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Tehran University of Medical Sciences

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: