This is a prospective, randomized, single blinded, controlled clinical trial designed to compare the clinical effects of sedation with dexmedetomidine versus propofol in patients undergoing cardiac surgery.
patients undergoing open heart surgery with the use of cardiopulmonary bypass (including coronary artery bypass grafting, valve repair/replacement, and combined)
left ventricular ejection fraction (LVEF) >40%.
preoperative atrial fibrillation
previous history of interventionally treated arrhythmias
second and third degree atrioventricular block
bradycardia with heart rate ≤50/min
Parallel
Dexmedetomidine
DrugUpon arrival to the intensive care unit after open heart surgery, the patients will be sedated with continuous dexmedetomidine infusion in doses 0.2-0.7 mcg/kg/h.
Propofol
DrugUpon arrival to the intensive care unit after open heart surgery, the patients will be sedated with continuous propofol infusion in doses 1-2 mg/kg/h.
Occurrence of postoperative delirium
Assessment of delirium will be performed using the confusion assessment method for intensive care unit (CAM-ICU) at any time in the first five days after surgery
MV duration
Duration of mechanical ventilation
ICU length of stay
Total duration of stay in the intensive care unit
Hospital length of stay
Total duration of stay in hospital
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