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Erector Spinae Versus Intercostal Nerve Blocks With Liposomal Bupivacaine for Analgesia in Thoracic Surgery

ConditionLung Cancers
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-90
SponsorGeorge Washington University

About this trial

This clinical trial compares efficacy in postoperative pain management in thoracic surgery between erector spinae block versus liposomal bupivacaine injections.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Video assisted pulmonary resection, pleurodesis or decortication

Disqualifiers

Allergy to local anesthetics

Patient undergoing bilateral surgery

Surgery is emergent as deemed by the principal investigator

Trial design

Design model

Parallel

Treatments tested in this trial

  • Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)

    Drug

    preoperative erector spinae block with bupivacaine (Marcaine®)

  • Intercostal nerve block

    Drug

    intraoperative intercostal nerve block with liposomal bupivacaine (Exparel®)

Treatment groups

120 Participants
are divided into 2 treatment groups
Group A: Preoperative Erector Spinae Block (ESB)(Bupivacaine)(Marcaine®)Active comparator 2 interventions
Group B: Intraoperative Intercostal Nerve Block (INB)(Liposomal Bupivacaine)(Exparel®)Active comparator 2 interventions

Trial outcomes

Primary outcomes

1

Postoperative pain control assessment

Study team will assess postoperative pain scores at 6, 12, 24 and 48 hours (Minimum numerical pain score of 0 and a maximum of 10)

Time frame
Up to 48 hours postoperatively
2

Morphine equivalent assessment

Study team will collect information on all administered pain medications to calculate morphine equivalents

Time frame
Up to 72 hours postoperatively

Secondary outcomes

1

Postoperative pain control assessment

Study team will assess postoperative pain scores at 72 hours (Minimum numerical pain score of 0 and a maximum of 10)

Time frame
Up to 72 hours postoperatively

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

George Washington University

Lead sponsor

Source ClinicalTrials.gov
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