Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study

ConditionChalazion

Trial statusRecruiting

Trial phasePhase 3

Trial typeInterventional

Biological sexAll

Age18+

SponsorUniversity of Washington

About this trial

Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Single or multiple chalazia in a single eyelid

Disqualifiers

Chalazia present for less than one month and no previous injection or incision and curettage

Trial design

Design model

Single group

Treatments tested in this trial

5-fluorouracil Injection
Drug
If the chalazion is present at follow-up visit, another injection of 5-FU will be given.
Triamcinolone Acetonide
Drug
If chalazion present at follow-up, another Triamcinolone injection will be done.
Incision and Curettage
Procedure/Surgery
If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.
Triamcinolone Acetonide/5-fluorouracil mixture
Drug
If chalazion persists at follow-up visit, another injection of triamcinolone/5-FU mixture will be done.

Treatment groups

120 Participants

are divided into 4 treatment groups

Group A: Incision and CurettageActive comparator 1 intervention

Group B: Injection of Triamcinolone AcetonideActive comparator 2 interventions

Group C: Injection of 5-fluorouracilActive comparator 2 interventions

Group D: Injection of triamcinolone/5FU mixtureActive comparator 2 interventions

Trial outcomes

Primary outcomes

Size of chalazion

Time frame

4 weeks

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Washington

Lead sponsor

Source ClinicalTrials.gov

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